CFFOUNDRY
04 / RESEARCH
04 / RESEARCH
The research foundry

REAL COHORTS.
Synthetic futures. Prospective learning.

CardioFoundry is being built as a research environment as well as a patient and clinical product: learn from real research cohorts, generate synthetic cardiovascular states, test engines before deployment, and eventually collect structured prospective outcomes into the ontology.

128,809real research participants / source universe underlying current modeling work
FILM / RESEARCH
A cardiovascular research loop

EVIDENCE SHOULD
compound.

Follow the research path from real-world data to state construction, synthetic cohorts, engine testing, and prospective evidence.

CURRENT / QUALIFIEDPLANNED / PROJECTED
REAL-WORLD RESEARCH UNIVERSE128,809participants / records
CARDIOVASCULAR STATE
PressureAtherogenicMetabolicAdipositySmokingRenalInflammatory
PHENOTYPE → STATE
SYNTHETIC PATIENT GENERATORPROJECTEDsimulate states · build cohorts · explore edge cases
ENGINE LABTEST BEFORE DEPLOYMENTcohort behavior · edge cases · validation
PROSPECTIVE ONTOLOGYPROJECTEDobservations · interventions · outcomes · provenance
REAL EVIDENCE→STATE→SYNTHETIC→TEST→PROSPECTIVE→ONTOLOGY

04.1 / QUALIFICATION
A qualification snapshot

THE SCIENCE HAS
to survive its own tests.

CardioFoundry’s foundational Heart Score architecture was qualified on held-out data before becoming the frozen T6 foundation.

28,051validation participants
28,632deployment participants
0.999997Spearman agreement
0.073p95 absolute difference
0%>2 point difference

Qualification metrics describe internal technical agreement for the frozen T6 implementation. They are not claims of clinical outcome benefit.

04.2 / RESEARCH MODES
Three complementary modes

OBSERVE. SIMULATE.
Then learn prospectively.

01 / REALReal-world cohort analysis

Qualified research datasets with preserved phenotype definitions, missingness, covariates, model lineage, and validation.

02 / SYNTHETICSynthetic patient + cohort generation

Planned simulation layer for stress-testing engines, exploring edge states, and designing research without substituting synthetic data for clinical truth.

FOURTH PILLAR / PROSPECTIVE DATAProspective ontology collection

Planned structured capture of observations, interventions, outcomes, time, and provenance so evidence can accumulate longitudinally.